Phenotypes Associated with This Genotype

Genotype
MGI:3770518

• Allelic Composition: Kras^tm2Tyj/Kras⁺
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:68981 , J:129627 )

• Background Sensitivity: mean age at death is ~350 days on pure 129/Sv background compared to 300 days on mixed background (J:68981)

• average lifespan is 373 days (J:68981)

neoplasm

increased tumor incidence ( J:129627 )

• mice develop adenocarcinomas, adenomas, lymphomas, mesotheliomas, angiosarcomas, fibrosarcomas, squamous carcinomas, rectal mucinous adenocarcinomas, melanomas, and papillomas

increased lymphoma incidence ( J:129627 )

increased T cell derived lymphoma incidence ( J:68981 )

• Background Sensitivity: ~10% of animals develop thymic lymphoma; incidence is lower than on pure 129/Sv background

increased carcinoma incidence ( J:129627 )

increased lung adenocarcinoma incidence ( J:136369 )

• develop lung adenocarcinomas by 6-8 months of age

• treatment of mice with PX-866, a PI3K inhibitor, decreases lung lesion volume and multiplicity

increased squamous cell carcinoma incidence ( J:129627 )

increased sarcoma incidence ( J:129627 )

increased fibrosarcoma incidence ( J:129627 )

increased hemangiosarcoma incidence ( J:129627 )

increased mesothelioma incidence ( J:129627 )

• 4 of 48 mice develop mesothelioma with no occurrence of peritoneal mesothelioma

increased papilloma incidence ( J:129627 )

increased skin papilloma incidence ( J:68981 )

• Background Sensitivity: about 40% of mice develop skin papillomas, with slightly higher incidence than on mixed 129 and C57BL/6 background

integument

increased skin papilloma incidence ( J:68981 )

• Background Sensitivity: about 40% of mice develop skin papillomas, with slightly higher incidence than on mixed 129 and C57BL/6 background

respiratory system

increased lung adenocarcinoma incidence ( J:136369 )

• treatment of mice with PX-866, a PI3K inhibitor, decreases lung lesion volume and multiplicity

• develop lung adenocarcinomas by 6-8 months of age

abnormal bronchus morphology ( J:136369 )

• a subset of mutant terminal bronchi contain 4 to 7 bronchioalveolar stem cells (BASCs) compared to 3 of fewer in wild-type bronchi, indicating expansion of BASCs

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:68981 )

• Background Sensitivity: ~10% of animals develop thymic lymphoma; incidence is lower than on pure 129/Sv background

immune system

increased T cell derived lymphoma incidence ( J:68981 )

• Background Sensitivity: ~10% of animals develop thymic lymphoma; incidence is lower than on pure 129/Sv background

hematopoietic system

increased T cell derived lymphoma incidence ( J:68981 )

• Background Sensitivity: ~10% of animals develop thymic lymphoma; incidence is lower than on pure 129/Sv background

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
lung cancer		DOID:1324	OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210	J:68981 , J:136369