hematopoietic system
N |
• at 3 and 6 months of age mice are not anemic despite disrupted iron homeostasis
|
• at 6 months of age, reticulocytes and mature erythrocytes have reduced cellular hemoglobin
• at 12 months of age hemoglobin content of erythrocytes remains reduced compared to wild-type controls
|
• at 6 months of age, reticulocytes and mature erythrocytes have reduced cell volume
• at 12 months of age mean cell volume of erythrocytes remains reduced compared to wild-type controls
|
• at 12 months of age spleen iron content is increased compared to controls
|
homeostasis/metabolism
• at 12 months of age spleen iron content is increased compared to controls
|
• significant reduction in liver non-heme iron at 6 and 12 months of age
|
immune system
• at 12 months of age spleen iron content is increased compared to controls
|
liver/biliary system
• significant reduction in liver non-heme iron at 6 and 12 months of age
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
NOT | hemochromatosis type 4 | DOID:0111028 |
OMIM:606069 |
J:129846 |