Analysis Tools
vision/eye
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• levels of rhodopsin within the outer segments are 6% that of wild-type mice
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• occurs in mice by one year of age
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• is apparent in mice 4 weeks of age
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• outer segment layer shortens as mice age with differences visible by 12 weeks of age
• mice show better preservation of the OS compared to Rpe65tm1Tmr homozygotes
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• lipid-like inclusions form in the RPE of mice by 8 weeks of age
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• occurs as mice age with the thickness being half that of wild-type mice by one year of age
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• light sensitivity in 8 week old mice is reduced by about 2.5 log units as measured by the luminance required to generate a half-maximal b-wave under scotopic conditions
• b-wave amplitude generated by light exposure decreases between 12 and 24 weeks of age
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• rhodopsin regeneration in light-bleached retinas is slower and reaches a plateau at about half the maximal level of non-bleached, dark-adapted mice
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pigmentation
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• lipid-like inclusions form in the RPE of mice by 8 weeks of age
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homeostasis/metabolism
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• 11-cis-retinal levels are reduced by 94 to 97% in dark adapted retinas as compared to age matched controls
• retinyl esters accumulate in the eye at a rate of 13 pmol/day until the increases stop at 24 weeks of age
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nervous system
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• levels of rhodopsin within the outer segments are 6% that of wild-type mice
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• occurs in mice by one year of age
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• is apparent in mice 4 weeks of age
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• outer segment layer shortens as mice age with differences visible by 12 weeks of age
• mice show better preservation of the OS compared to Rpe65tm1Tmr homozygotes
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| retinitis pigmentosa 20 | DOID:0110353 |
OMIM:613794 |
J:130076 | |
