Phenotypes Associated with This Genotype

Genotype
MGI:3772194

cn6

• Allelic Composition: Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp; Rnf2^tm1Mvi/Rnf2^tm1Mvi; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:130397 )

• mice die at 11 weeks after treatment with pIpC with splenomegalia and hepatomegalia

hematopoietic system

hematopoietic system phenotype ( J:130397 )

N • the deficits in splenocytes, bone marrow cells and pre-B cells observed in Rnf2^tm1Mvi/Rnf2^tm1Mvi Tg(Mx1-cre)1Cgn mice treated with pIpC at 6 to 12 weeks is not observed

enlarged spleen ( J:130397 )

abnormal common myeloid progenitor cell morphology ( J:130397 )

• following treatment with pIpC at 6 to 12 weeks, mice exhibit an increase in myeloid colony forming units relative to wild-type mice

neoplasm

increased lymphoma incidence ( J:130397 )

• following treatment with pIpC, mice develop lymphomas at an earlier age of onset compared to in Cdkn2a^tm1Rdp homozygotes

liver/biliary system

enlarged liver ( J:130397 )

immune system

enlarged spleen ( J:130397 )

growth/size/body

enlarged liver ( J:130397 )

enlarged spleen ( J:130397 )