Phenotypes Associated with This Genotype

Genotype
MGI:3772367

• Allelic Composition: A^vy/a
• Genetic Background: involves: C3H/HeJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Spectrum of coat colors in A^vy/a mice

growth/size/body

obese ( J:117156 )

pigmentation

abnormal coat/hair pigmentation ( J:117156 )

• variable coat color ranging from yellow, mosaic yellow/agouti, or pseudoagouti

variegated coat color ( J:117156 )

neoplasm

increased tumor incidence ( J:117156 )

integument

abnormal coat/hair pigmentation ( J:117156 )

• variable coat color ranging from yellow, mosaic yellow/agouti, or pseudoagouti

variegated coat color ( J:117156 )

cellular

abnormal epigenetic regulation of gene expression ( J:117156 )

• sires mated with a/a dams, but not dams mated with a/a sires, that were supplemented with methyl donors ((folate, choline, betaine, vitamin B12, zinc, and methionine) during pregnancy show a significant shift in the spectrum of color phenotypes toward pseudoagouti, indicating that in utero methyl donor supplementation affects the somatic epigenetic state of the A^vy allele only when the allele is derived from the male

• F1 pseudoagouti females that had been exposed to methyl donors in utero from E8.5 to E15.5 and mated to a/a males without further methyl donor supplementation, produce offspring (F2) showing a sift toward pseudoagouti coloration, indicating that diet/environment has an enduring influence on succeeding generations, independent of later changes in diet

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:13142 , J:117156