Phenotypes Associated with This Genotype

Genotype
MGI:3772457

• Allelic Composition: Tg(CAG-SAC/EGFP)35Rang/0; Tg(TRAMP)8247Ng/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased tumor incidence ( J:125633 )

♂ • by 3 months, 50% of mice develop high-grade prostatic intraepithelial neoplasm; by 6 months, only 21.4% of animals have progressed to adenocarcinoma

cellular

increased apoptosis ( J:125633 )

♂ • prostatic adenocarcinomas and epithelial neoplasms show significantly more apoptotic cells relative to tumors in Tg(TRAMP)8247Ng single transgenic mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:125633