Phenotypes Associated with This Genotype

Genotype
MGI:3772798

• Allelic Composition: Etv6^{tm3(NTRK3)Sho}/Etv6⁺; Tg(Wap-cre)11738Mam/0
• Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:130323 )

• nulliparous and parous females develop multifocal mammary tumors as early as 4 months of age with preceding lobuloalveolar hyperplasia

• tumors exhibit heterogeneous morphology and rate of progression but are highly invasive and transplantable

• on occasion transplanted tumors exhibit metastasis to the lymph nodes and lungs

• mammary tumors are derived from committed alveaolar bipotent or CD61+ cells

endocrine/exocrine glands

mammary gland alveolar hyperplasia ( J:130323 )

♀ • nulliparous and parous female mice exhibit lobuloalveolar hyperplasia prior to developing mammary tumors

increased mammary gland tumor incidence ( J:130323 )

• nulliparous and parous females develop multifocal mammary tumors as early as 4 months of age with preceding lobuloalveolar hyperplasia

• tumors exhibit heterogeneous morphology and rate of progression but are highly invasive and transplantable

• on occasion transplanted tumors exhibit metastasis to the lymph nodes and lungs

• mammary tumors are derived from committed alveaolar bipotent or CD61+ cells

integument

mammary gland alveolar hyperplasia ( J:130323 )

♀ • nulliparous and parous female mice exhibit lobuloalveolar hyperplasia prior to developing mammary tumors

increased mammary gland tumor incidence ( J:130323 )

• nulliparous and parous females develop multifocal mammary tumors as early as 4 months of age with preceding lobuloalveolar hyperplasia

• tumors exhibit heterogeneous morphology and rate of progression but are highly invasive and transplantable

• on occasion transplanted tumors exhibit metastasis to the lymph nodes and lungs

• mammary tumors are derived from committed alveaolar bipotent or CD61+ cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:130323