Phenotypes Associated with This Genotype

Genotype
MGI:3772917

cx5

• Allelic Composition: Slit1^tm1.1Matl/Slit1^tm1.1Matl; Slit2^tm1Matl/Slit2^tm1Matl
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:130430 )

• mice die at birth

nervous system

nervous system phenotype ( J:130430 )

N • mice exhibit normal numbers of interneurons during development

abnormal olfactory lobe morphology ( J:119469 )

• density of LOT (guidepost) cells is slightly decreased rostrally near the ventral part of the olfactory bulb

abnormal olfactory tract morphology ( J:119469 )

• highly defasciculated into small axonal bundles fanned all over the ventral side of the telencephalon although a subset of axons continue on the normal trajectory, at E18.5

• medial axons are more severely affected than lateral axons

abnormal embryonic/fetal subventricular zone morphology ( J:130430 )

• at E13.5 and E16.5, cell proliferation of ganglionic eminences in the subventricular zone is increased compared to in Slit1^tm1.1Matl homozygotes

abnormal neurite morphology ( J:130430 )

• in the subventricular zone/intermediate zone and subplate, mic exhibit an increased in neurite process length is, the number of neurites, and the degree of branching