Phenotypes Associated with This Genotype

Genotype
MGI:3773447

• Allelic Composition: A^y/A
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased brown adipose tissue amount ( J:131039 )

• female mice have a 6-fold gain in weight of BAT compared to littermate controls

increased gonadal fat pad weight ( J:131039 )

• female mice have almost a 7-fold gain in weight of fat pad

increased inguinal fat pad weight ( J:131039 )

• female mice have a greater than 6-fold gain in weight of fat pad

increased retroperitoneal fat pad weight ( J:131039 )

• female mice have almost a 6-fold gain in weight of fat pad

increased percent body fat/body weight ( J:131039 )

• female mice have almost a 4-fold gain in percentage of body fat compared to littermate controls

• male mice have almost a 1.8-fold gain in percentage of body fat compared to littermate controls

behavior/neurological

increased food intake ( J:131039 )

• 18 week old mice eat about 1.4 times more food during a 7 day period compared to wild-type controls

decreased locomotor activity ( J:131039 )

• the locomotor activity of mice is about half that of wild-type mice

growth/size/body

obese ( J:131039 )

• by 23 weeks of age, female mice have almost double the weight compared to their wild-type littermate controls

increased body length ( J:131039 )

• female but not male mice have a significant 5% increase in their body length

increased susceptibility to weight gain ( J:131039 )

• mice gain weight at a greater rate than littermate controls starting at six weeks of age

increased liver weight ( J:131039 )

• female mice have almost a 2-fold gain in weight of the liver

homeostasis/metabolism

increased circulating leptin level ( J:131039 )

• circulating levels of leptin are over 12-fold higher compared to littermate controls

liver/biliary system

increased liver weight ( J:131039 )

• female mice have almost a 2-fold gain in weight of the liver

pigmentation

yellow coat color ( J:131039 )

• mice have a yellow coat color

integument

yellow coat color ( J:131039 )

• mice have a yellow coat color

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:131039