Phenotypes Associated with This Genotype

Genotype
MGI:3773672

• Allelic Composition: Ndn^tm1.1Mus/Ndn⁺
• Genetic Background: B6.129S2-Ndn^tm1.1Mus

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

In vivo analysis of axonal growth in Ndn^tm1.1Mus/Ndn⁺ embryos

behavior/neurological

impaired coordination ( J:119656 )

• time spent in an accelerated rotarod is reduced and the latency to reach the goal platform in the beam walking test is increased in mice with a paternally inherited allele

decreased thermal nociceptive threshold ( J:119656 )

• mice with a paternally inherited allele show reduced withdrawal latency on a hot plate test compared to wild-type, indicating reduced pain threshold

nervous system

abnormal sensory neuron innervation pattern ( J:119656 )

• cutaneous innervation in the hindpad is reduced in mice with a paternally inherited allele, as indicated by reduced number of CGRP-immunoreactive fibers

abnormal dorsal root ganglion morphology ( J:119656 )

• neurite outgrowth from DRG explants isolated from E13.5 mutants with a paternally inherited allele and grown in culture is reduced by 18.3%

abnormal proprioceptive neuron morphology ( J:119656 )

• partial loss of proproceptive (TrkC expressing) sensory neurons in mice with a paternally inherited allele

• afferent projections from the proprioceptive neurons are reduced in the intermediate spinal cord of E17.5 mice with a paternally inherited allele

abnormal lumbar dorsal root ganglion morphology ( J:119656 )

• mice with a paternally inherited allele, show a 37% reduction in the L1 dorsal root ganglia (DRG) volume at P0

• lumbar DRGs of mice with a paternally inherited allele show a reduction of 26.2% in the density of TrkA-expressing cells and a reduction of 37.8% in TrkC-positive neurons

• mutants with a paternally inherited allele exhibit an increase of apoptosis in lumbar DRG at E12.5, restricted to neurons and does not affect progenitors

abnormal nervous system electrophysiology ( J:119656 )

• when this allele is paternally inherited, the monosynaptic reflex response on the plantar muscle shows a higher H-wave amplitude and H/M amplitude ratio

cellular

maternal imprinting ( J:119656 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Prader-Willi syndrome		DOID:11983	OMIM:176270	J:119656