Phenotypes Associated with This Genotype

Genotype
MGI:3774122

hm1

• Allelic Composition: Cftr^tm1Hgu/Cftr^tm1Hgu
• Genetic Background: CF/1Ztm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Generation 27 and 28 Cftr^tm1Hgu/Cftr^tm1Hgu mice exhibit focal hypertrophy of goblet cells

mortality/aging

lethality, incomplete penetrance ( J:112752 )

• Background Sensitivity: in early generations, 8-10% die of intestinal obstruction around weaning, survival is 76% at 3 months of age for the F8-F10 generations, early deaths are still seen at F18, but by the 25th generation, no increased mortality over wild-type is seen

digestive/alimentary system

abnormal ileal goblet cell morphology ( J:112752 )

• F28 mice show focal hypertrophy of goblet cells in the ileum, but not in the jejunum

intestinal obstruction ( J:112752 )

• Background Sensitivity: 8-10% of mutants in the early generations die of intestinal obstruction at weaning, however later generations do not exhibit intestinal blockage

reproductive system

reproductive system phenotype ( J:112752 )

N • males and females are fertile

cellular

abnormal ileal goblet cell morphology ( J:112752 )

• F28 mice show focal hypertrophy of goblet cells in the ileum, but not in the jejunum