Phenotypes Associated with This Genotype

Genotype
MGI:3774345

hm8

• Allelic Composition: Lepr^db/Lepr^db
• Genetic Background: BKS.Cg-Dock7^m +/+ Lepr^db/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal intestinal epithelium morphology ( J:124815 )

• reduced levels of occludin in intestinal sections

• zonula occludens 1 has a discontinuous distribution

abnormal digestive system physiology ( J:124815 )

• transepithelial resistance in the epithelium is reduced, indictive of a disrupted mucosal barrier function

immune system

abnormal chemokine secretion ( J:124815 )

• increased release of monocyte chemo attractant protein by hepatic stellate cells

increased interleukin-6 secretion ( J:124815 )

• increased release by hepatic stellate cells

abnormal acute inflammation ( J:124815 )

• higher levels of endotoxin are found in portal blood (entotoxemia)

increased susceptibility to endotoxin shock ( J:124815 )

• increased succeptibility of hepatic stellate cells to LPS

liver inflammation ( J:124815 )

liver/biliary system

liver inflammation ( J:124815 )