Phenotypes Associated with This Genotype

Genotype
MGI:3774583

• Allelic Composition: Pdx1^tm1Cvw/Pdx1^tm4Cvw; Tg(Ins2-cre)25Mgn/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased pancreatic beta cell proliferation ( J:130389 )

• proliferation of insulin+ cells is decreased

increased pancreatic alpha cell proliferation ( J:130389 )

• proliferation of glucagon+ cells is increased

endocrine/exocrine glands

decreased pancreatic beta cell proliferation ( J:130389 )

• proliferation of insulin+ cells is decreased

increased pancreatic alpha cell proliferation ( J:130389 )

• proliferation of glucagon+ cells is increased

abnormal pancreas morphology ( J:130389 )

• proliferation of Pdx1- cells is decreased compared to in wild-type pancreas

increased pancreatic alpha cell number ( J:130389 )

• beginning at E18.5, the number of glucagon+ cells is increased

• by one month of age mice are overtly diabetic with increased numbers of glucagon+ cells

• proliferation of glucagon+ cells is increased

decreased pancreatic beta cell number ( J:130389 )

• the number of insulin+ cells decreases as the number of glucagon+ cells increases

• proliferation of insulin+ cells is decreased

• by one month of age mice are overtly diabetic with decreased insulin immunoreactivity in remaining insulin+ cells

increased pancreatic delta cell number ( J:130389 )

• by one month of age mice are overtly diabetic with increased numbers of somatostatin+ cells

disorganized pancreatic islets ( J:130389 )

• glucagon+ and somatostatin+ cells are scattered throughout the islet instead of localized to the periphery as in wild-type mice

homeostasis/metabolism

increased circulating glucose level ( J:130389 )

• as early as P1

decreased circulating insulin level ( J:130389 )

• insulin levels following administration of glucose are lower in males and females compared to wild-type mice

impaired glucose tolerance ( J:130389 )

• unlike male mice, females exhibit only mild glucose intolerance compared to wild-type females

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:130389