Phenotypes Associated with This Genotype

Genotype
MGI:3774840

cn2

• Allelic Composition: Atf2^tm3Nicj/Atf2^tm3Nicj; Tg(KRT14-cre)1Efu/?
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased skin papilloma incidence ( J:131564 )

• the median appearance of skin papillomas after topical application of carcinogens is five to six weeks earlier than in littermate controls

• mice have significantly greater numbers of papillomas 20 weeks after carcinogen treatment with a mean of 7 compared to 3 in littermate controls

integument

epidermal hyperplasia ( J:131564 )

• the percentage of proliferating epithelial cells after TPA administration is twice that of littermate controls

• reduced levels of active caspase 3 were observed in the skin of mice treated with carcinogens suggesting apoptosis levels might be lower

thick epidermis ( J:131564 )

• mice develop a significantly thickened hyperdermis after three topical applications of TPA

• thickness is twice that of wild-type mice after TPA application

increased skin papilloma incidence ( J:131564 )

• the median appearance of skin papillomas after topical application of carcinogens is five to six weeks earlier than in littermate controls

• mice have significantly greater numbers of papillomas 20 weeks after carcinogen treatment with a mean of 7 compared to 3 in littermate controls