Phenotypes Associated with This Genotype

Genotype
MGI:3774843

ht16

• Allelic Composition: Lepr^db/Lepr⁺
• Genetic Background: involves: C57BLKS/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:71934 )

increased circulating glucose level ( J:71934 )

♀ • fasting glucose levels elevated 25% during pregnancy

impaired glucose tolerance ( J:71934 , J:219658 )

• profound glucose intolerance during pregnancy (J:71934)

• glucose levels 41% higher in a glucose tolerance test at 30 and at 60 minute time points (J:71934)

• 45-55% higher glucose levels after a glucose challenge but dramatically improved by leptin treatment and glucose levels reduced 33 and 30% in glucose tolerance tests at 30 and 60 minute time points (J:71934)

• females exhibit impaired glucose tolerance during pregnancy (J:219658)

• both male and female heterozygous offspring have impaired glucose tolerance irrespective of maternal environment (heterozygous or wild-type mothers) (J:219658)

abnormal hormone level ( J:71934 )

♀ • elevated placental leptin levels in pregnant females

abnormal circulating insulin level ( J:71934 )

♀ • 2.2X increase in fasting insulin during pregnancy compared to a 3X increase in controls

♀ • leptin treatment results in a 14% reduction in insulin levels compared to a 45% reduction in controls

decreased circulating insulin level ( J:219658 )

♀ • pregnant dams exhibit lower fasting insulin levels than wild-type mothers

increased circulating leptin level ( J:219658 )

• mothers exhibit higher circulating leptin levels than wild-type mothers

• heterozygous offspring exhibit an increase in leptin levels at 6 months of age

decreased response to leptin ( J:71934 )

• birth weights significantly heavier than controls and unaffected by maternal leptin treatment unlike controls where maternal leptin treatment causes a decrease in birth weights

• leptin treatment results in a 14% reduction in insulin levels compared to a 45% reduction in controls

embryo

enlarged placenta ( J:219658 )

• placentas from heterozygous fetuses are larger than those of wild-type fetuses, irrespective of maternal genotype

behavior/neurological

increased food intake ( J:71934 )

♀ • food intake 11% greater than controls during pregnancy

♀ • leptin treatment suppresses food intake to near control levels

growth/size/body

increased birth weight ( J:219658 )

• heterozygous fetuses carried by wild-type dams exhibit a 5% higher birth weight than wild-type littermates

• heterozygous fetuses from heterozygous mothers are 3% bigger than wild-type littermates

• however, wild-type pups from heterozygous mothers are no bigger than wild-type fetuses carried by wild-type mothers

increased body weight ( J:219658 )

• heterozygous pregnant dams are heavier than wild-type mothers at E18.5

• male and female heterozygous offspring from both normal and complicated pregnancies, are heavier than wild-type littermates at 3 and 6 months of age

increased susceptibility to weight gain ( J:71934 )

♀ • 33% greater maternal weight gain

♀ • maternal body weight at term 24% greater than controls

adipose tissue

increased total body fat amount ( J:71934 )

♀ • 20% greater adipose tissue mass during pregnancy than in controls

cellular

maternal effect ( J:219658 )

• wild-type males born to heterozygous mothers are heavier than wild-type mice born to wild-type mothers, but postnatal weight gain of female offspring is not affected by the maternal environment

• offspring born from heterozygous mothers with gestational diabetes have lower fasting insulin levels and worse glucose tolerance than offspring born from wild-type mothers