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Phenotypes Associated with This Genotype
Genotype
MGI:3774850
Allelic
Composition		 Atxn7tm1Hzo/Atxn7+
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atxn7tm1Hzo mutation (1 available); any Atxn7 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Altered rod photoreceptor nuclear architecture in Tg(RHO-SCA7)R7EJman/0 and Atxn7tm1Hzo/Atxn7+ mice, but not in Tg(RHO-SCA7)R7NJman/0 mice

mortality/aging

vision/eye
abnormal retina rod cell morphology ( J:107098 )
• rod photoreceptors exhibit chromatin decondensation; rod nuclei contain more euchromatin and show a reduced and disorganized heterochromatin territory

nervous system
abnormal retina rod cell morphology ( J:107098 )
• rod photoreceptors exhibit chromatin decondensation; rod nuclei contain more euchromatin and show a reduced and disorganized heterochromatin territory

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
spinocerebellar ataxia type 7 DOID:0050958 OMIM:164500
 J:107098

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory