Phenotypes Associated with This Genotype

Genotype
MGI:3774853

hm12

• Allelic Composition: Lepr^db/Lepr^db
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

increased bone volume ( J:60001 )

• 3 fold increase in bone volume

abnormal skeleton development ( J:60001 )

• rate of new bone formation increased at both 3 and 6 months

abnormal osteoclast differentiation ( J:60001 )

• increased numbers of osteoclasts

hematopoietic system

abnormal osteoclast differentiation ( J:60001 )

• increased numbers of osteoclasts

immune system

abnormal osteoclast differentiation ( J:60001 )

• increased numbers of osteoclasts

cellular

abnormal osteoclast differentiation ( J:60001 )

• increased numbers of osteoclasts