Analysis Tools
cellular
|
• middle ear cavity epithelium of young mice has increased numbers of goblet cells
|
mortality/aging
|
• Background Sensitivity: no homozygous pups are recovered at weaning when parental animals are backcrossed 2 or less generations to CBA/J; from the F3 generation onward on a 129S6-CBA/J mixed background, most animals survive to 21 days of age
|
homeostasis/metabolism
|
• middle ear effusions with or without air bubbles are observed through the ear drum of mutants at postnatal days 14-16
• 3-week old mice show middle ear effusions, consistent with otitis media; mice show serous effusions with few granulocytes, while older mice have more purulent effusions with abundant granulocytes
|
growth/size/body
|
• incomplete fusion of palatal bones is seen in skulls of newborn mutants
|
|
• mutant and wild-type body weights are comparable at birth, but adult mutants weigh 25% less than wild-type littermates and at 10 months of age, average weight is significantly lower than wild-type
|
hearing/vestibular/ear
|
• eustachian tube's medial osseus segment and opening within the tympanic cavity (OpTC) are abnormal and diminuitive, being about half the size of wild-type
• opening within the tympanic cavity (OpTC) is narrowed and abnormally positioned at the anterior perimeter of the middle ear
• some mice have a polyp obstructing the OpTC
|
|
• middle ear cavity epithelium of young mice is swollen
• by 16 months, cilia density is diminished and epithelial swelling is more pronounced
|
|
• middle ear cavity epithelium of young mice has increased numbers of goblet cells
|
|
• at postnatal days 11-12, middle ear cavity of mutants remains full of mesenchyme whereas middle ear cavity of wild-type mice is largely aerated with mesenchymal cells found only near ossicles
|
|
• middle ear effusions with or without air bubbles are observed through the ear drum of mutants at postnatal days 14-16
• 3-week old mice show middle ear effusions, consistent with otitis media; mice show serous effusions with few granulocytes, while older mice have more purulent effusions with abundant granulocytes
|
|
• 3-week old mice all display hypervascularity of the tympanic membrane along the manubrium of the malleus
|
|
• tympanic membrane retraction is observed at postnatal days 14-16
• at 3 weeks all mutants display marked tympanic membrane retraction with hypervascularity
|
|
• some mice have a polyp obstructing the OpTC
|
|
• 10-week old mice show significant functional loss in peripheral auditory sensitivity relative to wild-type
|
|
• 10-week old mice show significant functional loss in peripheral auditory sensitivity relative to wild-type
|
|
• all mice show similar degree of bilateral otitis media with effusion when allele is on CBA/J, C57BL/6, BALB/c, and Swiss Webster backgrounds, whereas wild-type mice of those strains show no signs of inflammation
|
reproductive system
 |
• homozygous males are sterile or have severely diminished fertility; only 2 litters were produced by 13 homozygous males of reproductive age compared to normal fertility of wild-type and heterozygous males
|
craniofacial
|
• incomplete fusion of palatal bones is seen in skulls of newborn mutants
|
digestive/alimentary system
|
• incomplete fusion of palatal bones is seen in skulls of newborn mutants
|
immune system
|
• all mice show similar degree of bilateral otitis media with effusion when allele is on CBA/J, C57BL/6, BALB/c, and Swiss Webster backgrounds, whereas wild-type mice of those strains show no signs of inflammation
|
skeleton
|
• incomplete fusion of palatal bones is seen in skulls of newborn mutants
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| otitis media | DOID:10754 | J:131873 | ||
