Phenotypes Associated with This Genotype

Genotype
MGI:3776498

• Allelic Composition: Pkd1^tm1Bdgz/Pkd1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

kidney cyst ( J:130086 )

• when gross morphology is assessed, surface cysts are observed in 19% of mutants, the majority of which are older than 24 weeks; rare animals display cyst development at 6 weeks of age

• histologically, 30% of animals show cyst formation or tubular dilation between 6 and 78 weeks of age

dilated renal tubule ( J:130086 )

• histologically, 30% of animals show cyst formation or tubular dilation; animals with tubular dilation are <24 weeks of age

liver/biliary system

liver cyst ( J:130086 )

• when gross morphology is assessed, surface cysts are observed in 9% of mutants older than 40 weeks (seen in only 1 animal at 42 weeks)

endocrine/exocrine glands

pancreas cyst ( J:130086 )

• when gross morphology is assessed, surface cysts are observed in 1% of mutants older than 40 weeks

growth/size/body

pancreas cyst ( J:130086 )

• when gross morphology is assessed, surface cysts are observed in 1% of mutants older than 40 weeks

kidney cyst ( J:130086 )

• when gross morphology is assessed, surface cysts are observed in 19% of mutants, the majority of which are older than 24 weeks; rare animals display cyst development at 6 weeks of age

• histologically, 30% of animals show cyst formation or tubular dilation between 6 and 78 weeks of age

liver cyst ( J:130086 )

• when gross morphology is assessed, surface cysts are observed in 9% of mutants older than 40 weeks (seen in only 1 animal at 42 weeks)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
polycystic kidney disease 1		DOID:0110858	OMIM:173900	J:130086