Phenotypes Associated with This Genotype

Genotype
MGI:3776838

• Allelic Composition: Pax1^un/Pax1⁺; Tcf3^tm1Cmu/Tcf3^tm1Cmu
• Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:103567 )

• most mice die postnatally due to are cannibalization

reproductive system

infertility ( J:103567 )

nervous system

open neural tube ( J:103567 )

• mice are born with non-lethal neural tube defects at the lumbosacral region over which skin grows

spina bifida ( J:103567 )

renal/urinary system

abnormal renal/urinary system morphology ( J:103567 )

• mice exhibit high outflow tract resistance

immune system

abnormal T cell differentiation ( J:103567 )

• T cell transition to double positive is partially blocked

abnormal T cell subpopulation ratio ( J:103567 )

• the ratio of CD4 over CD8 T cells is reduced compared to in wild-type mice

limbs/digits/tail

curly tail ( J:103567 )

hematopoietic system

abnormal T cell differentiation ( J:103567 )

• T cell transition to double positive is partially blocked

abnormal T cell subpopulation ratio ( J:103567 )

• the ratio of CD4 over CD8 T cells is reduced compared to in wild-type mice

embryo

open neural tube ( J:103567 )

• mice are born with non-lethal neural tube defects at the lumbosacral region over which skin grows

spina bifida ( J:103567 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neural tube defect		DOID:0080074	OMIM:301410 OMIM:601634	J:103567