Analysis Tools
mortality/aging
| N |
• the Tnf null background prevents the lethality that occurs at E14.5 for Tbk1 homozygotes
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immune system
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• serum titers of antigen specific IgG in response to a DNA vaccine are almost 4-log lower than those in control
• when mice serve as bone marrow donors to irradiated control mice, similar defects in antigen specific IgG production after immunization are observed
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• serum titers of antigen specific IgG1 in response to a DNA vaccine are significantly less
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• serum titers of antigen specific IgG2a in response to a DNA vaccine are significantly les
• when mice serve as bone marrow donors to irradiated control mice, similar defects in antigen specific IgG2a production after immunization are observed
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• there is a 10-fold reduction in the number of antigen specific CD8 T cells two weeks after immunization with a DNA vaccine compared to vaccinated controls
• when mice are irradiated and receive wild-type bone marrow, CD8 T cells proliferate at a significantly reduced level upon exposure to antigen encoded in the DNA vaccine
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• there is a reduction in antigen specific CTL activity two weeks after immunization with a DNA vaccine compared to vaccinated controls
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• splenocytes from mice immunized with a DNA vaccine produce significantly less IFN-gamma upon stimulation with antigen in culture compared to vaccinated controls
• when mice serve as bone marrow donors to irradiated control mice, similar defects in IFN-gamma secretion after immunization are observed
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hematopoietic system
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• serum titers of antigen specific IgG in response to a DNA vaccine are almost 4-log lower than those in control
• when mice serve as bone marrow donors to irradiated control mice, similar defects in antigen specific IgG production after immunization are observed
|
|
• serum titers of antigen specific IgG1 in response to a DNA vaccine are significantly less
|
|
• serum titers of antigen specific IgG2a in response to a DNA vaccine are significantly les
• when mice serve as bone marrow donors to irradiated control mice, similar defects in antigen specific IgG2a production after immunization are observed
|
|
• there is a 10-fold reduction in the number of antigen specific CD8 T cells two weeks after immunization with a DNA vaccine compared to vaccinated controls
• when mice are irradiated and receive wild-type bone marrow, CD8 T cells proliferate at a significantly reduced level upon exposure to antigen encoded in the DNA vaccine
|
|
• there is a reduction in antigen specific CTL activity two weeks after immunization with a DNA vaccine compared to vaccinated controls
|
