Phenotypes Associated with This Genotype

Genotype
MGI:3777758

• Allelic Composition: Crygb^S11R/Crygb⁺
• Genetic Background: A/J-Crygb^S11R

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal lens morphology ( J:132502 )

• at 220-350 um from lens capsule, lenses display unique ringlike structure which causes abnormal light scattering

abnormal lens fiber morphology ( J:132502 )

• inner fiber cells of lenses show uneven toluidine blue staining with abnormally darkly stained areas at P3

• at P21, peripheral fiber cells are relatively normal, similar to wild-type

nuclear cataract ( J:132502 )

• mice display hazy nuclear cataracts by weaning age

• periphery of lens remains transparent, even in older mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 39 multiple types		DOID:0110236	OMIM:615188	J:132502