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Phenotypes Associated with This Genotype
Genotype
MGI:3777917
hm1
Allelic
Composition		 Hax1tm1Jni/Hax1tm1Jni
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hax1tm1Jni mutation (0 available); any Hax1 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:132627 )
• fail to survive beyond 14 weeks of age

behavior/neurological
impaired coordination ( J:132627 )
• progressive loss of motor coordination
abnormal locomotor activation ( J:132627 )
• progressive loss of activity

nervous system
increased neuron apoptosis ( J:132627 )
• extensive apoptosis of neurons in the striatum and cerebellum develops
astrocytosis ( J:132627 )
• extensive infiltration of astrocytes in the striatum

hematopoietic system
decreased bone marrow cell number ( J:132627 )
• loss of cellularity related to increase in apoptotic cells
decreased lymphocyte cell number ( J:132627 )
• loss with age in the spleen, thymus, and bone marrow
decreased immature B cell number ( J:132627 )
• preferential loss of pro- and pre-B cells
• increased apoptosis
decreased T cell number ( J:132627 )
• increased susceptibility to absence of cytokines
decreased double-positive T cell number ( J:132627 )
• equal to single positive cell loss
decreased single-positive T cell number ( J:132627 )
• equal to double positive cell loss

immune system
decreased lymphocyte cell number ( J:132627 )
• loss with age in the spleen, thymus, and bone marrow
decreased immature B cell number ( J:132627 )
• preferential loss of pro- and pre-B cells
• increased apoptosis
decreased T cell number ( J:132627 )
• increased susceptibility to absence of cytokines
decreased double-positive T cell number ( J:132627 )
• equal to single positive cell loss
decreased single-positive T cell number ( J:132627 )
• equal to double positive cell loss

cellular
increased neuron apoptosis ( J:132627 )
• extensive apoptosis of neurons in the striatum and cerebellum develops

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory