Phenotypes Associated with This Genotype

Genotype
MGI:3778823

• Allelic Composition: Vangl1^Gt(XL802)Byg/Vangl1^Gt(XL802)Byg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Abnormal orientation of hair cells of the cochlea in Vangl1^Gt(XL802)Byg/Vangl1^Gt(XL802)Byg embryos

hearing/vestibular/ear

abnormal orientation of cochlear hair cell stereociliary bundles ( J:132697 )

• modest but significant misorientation in all hair cell layers

• however, the number and organization of hair cell rows is not different from wild-type controls

cardiovascular system

cardiovascular system phenotype ( J:132697 )

N • unlike mice homozygous for Vangl2^Lp alone, nor outflow tract abnormalities are detected

nervous system

nervous system phenotype ( J:132697 )

N • unlike mice with mutations in Vangl2, no neural tube defects are detected

abnormal orientation of cochlear hair cell stereociliary bundles ( J:132697 )

• modest but significant misorientation in all hair cell layers

• however, the number and organization of hair cell rows is not different from wild-type controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	neural tube defect	DOID:0080074	OMIM:301410 OMIM:601634	J:132697