Phenotypes Associated with This Genotype

Genotype
MGI:3783528

• Allelic Composition: Rb1^tm3Tyj/Rb1^tm3Tyj; Rbl2^tm1Tyj/Rbl2^tm1Tyj; Tg(Nes-cre)1Atp/0
• Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased tumor-free survival time ( J:91406 )

• mice with mosaic cre expression due to maternal inheritance of Tg(Nes-cre)1Mrt exhibit an average tumor-free lifespan of 97 days but where sacrificed when moribund

vision/eye

abnormal retina apoptosis ( J:91406 )

• apoptosis levels are higher than in wild-type mice but not higher than in Rb1^tm3Tyj/Rb1^tm3Tyj Tg(Nes-cre)1Mrt mice

increased retinoblastoma incidence ( J:91406 )

• mice with mosaic cre expression due to maternal inheritance of Tg(Nes-cre)1Mrt exhibit bilateral retinoblastomas that invade surrounding muscle, exhibit rosettes, have foci with high levels of apoptosis and mitoses and are of amacrine lineage

neoplasm

increased retinoblastoma incidence ( J:91406 )

• mice with mosaic cre expression due to maternal inheritance of Tg(Nes-cre)1Mrt exhibit bilateral retinoblastomas that invade surrounding muscle, exhibit rosettes, have foci with high levels of apoptosis and mitoses and are of amacrine lineage

reproductive system

transmission ratio distortion ( J:91406 )

• fewer than expected mice are produced with maternal inheritance of Tg(Nes-cre)1Mrt

cellular

abnormal retina apoptosis ( J:91406 )

• apoptosis levels are higher than in wild-type mice but not higher than in Rb1^tm3Tyj/Rb1^tm3Tyj Tg(Nes-cre)1Mrt mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
retinoblastoma		DOID:768	OMIM:180200	J:91406