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Phenotypes Associated with This Genotype
Genotype
MGI:3784035
cx2
Allelic
Composition
Galk1tm1Stb/Galk1tm1Stb
Tg(Cryaa-AKR1B1)222Smch/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Galk1tm1Stb mutation (1 available); any Galk1 mutation (7 available)
Tg(Cryaa-AKR1B1)222Smch mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• mice develop cataracts in absence of high galactose diet; cataract formation is detected at P0 on nomral or 40% glucose diet
• cataracts are detected as vacuoles at the periphery of the lens

homeostasis/metabolism
• at P0, lenses have high levels of galactitol relative to controls


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory