Phenotypes Associated with This Genotype

Genotype
MGI:3784583

• Allelic Composition: Cryaa^tm1.1Ady/Cryaa^tm1.1Ady
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Lens opacity in Cryaa^tm1.1Ady/Cryaa⁺, and Cryaa^tm1.1Ady/Cryaa^tm1.1Ady mice and microphthalmia in Cryaa^tm1.1Ady/Cryaa^tm1.1Ady mice

vision/eye

increased lens epithelium apoptosis ( J:132296 )

increased lens fiber apoptosis ( J:132296 )

abnormal lens morphology ( J:132296 )

• increased amounts of alphaA-crystallin and alphaB-crystallin in the lens-insoluble fractions

cataract ( J:132296 )

• a rapid onset of cataract that stabilized between 8 and 12 weeks

• stage 3 and 4 lens opacities were observed in 5- and 16-week-old homozygous mice

nuclear cataract ( J:157274 )

• severe in the nuclear region of the lens in newborn mice

small lens ( J:132296 )

• weight of eyes are 60-70% less than wild-type and heterozygous littermates which was mainly due to the decrease in lens weight

microphthalmia ( J:132296 )

• severe microphthalmia

• weight of eyes are 60-70% less than wild-type and heterozygous littermates which was mainly due to the decrease in lens weight

cellular

increased lens epithelium apoptosis ( J:132296 )

increased lens fiber apoptosis ( J:132296 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 9 multiple types		DOID:0110266	OMIM:604219	J:132296