Phenotypes Associated with This Genotype

Genotype
MGI:3784684

• Allelic Composition: Tg(PDGFB-APPSwInd)J9Lms/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:62290 )

• at 5 to 7 months, mice exhibit amloid beta plaques

• between 16 and 21 months, all mice develop amyloid beta plaques

neurodegeneration ( J:62290 )

• neurodegeneration is indicated by an age dependent decrease in density of synaptophysin-immunoreactive presynaptic terminals

homeostasis/metabolism

amyloid beta deposits ( J:62290 )

• at 5 to 7 months, mice exhibit amloid beta plaques

• between 16 and 21 months, all mice develop amyloid beta plaques

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:62290