Phenotypes Associated with This Genotype

Genotype
MGI:3785397

• Allelic Composition: Ugt1^tm1Rhtu/Ugt1^tm1Rhtu
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Ugt1^tm1Rhtu/Ugt1^tm1Rhtu mice are jaundiced and show postnatal lethality

mortality/aging

postnatal lethality, complete penetrance ( J:133790 )

• all die within 2 weeks of birth

liver/biliary system

jaundice ( J:133790 )

• visibly jaundiced within 8 h of birth

• however, no signs of liver or kidney damage are detected

homeostasis/metabolism

increased circulating bilirubin level ( J:133790 )

• serum unconjugated bilirubin levels are 50- to 60-fold higher then in wild-type or heterozygous littermates

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Crigler-Najjar syndrome		DOID:3803	OMIM:218800	J:133790