Phenotypes Associated with This Genotype

Genotype
MGI:3789208

tg4

• Allelic Composition: Tg(TcraCl4,TcrbCl4)1Shrm/?
• Genetic Background: B10.Cg-H2^d Tg(TcraCl4,TcrbCl4)1Shrm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal CD8-positive, alpha-beta T cell differentiation ( J:99756 )

• the majority of mature CD8 T cells in the periphery express the transgenic T cell receptor (TCR) that is specific for influenza virus hemagglutinin (HA) peptide presented by MHC-Class I H2-K^d

• 40% of the CD8 T cells in the blood are reactive to HA peptide presented by H2-K^d

• most thymocytes also express the transgenic TCR

abnormal T cell subpopulation ratio ( J:99756 )

• skewing toward the development of single-positive CD8 T cells is evident in the thymus

• there are 4-fold more CD8 T cells than CD4 T cells found in the lymph nodes

hematopoietic system

abnormal CD8-positive, alpha-beta T cell differentiation ( J:99756 )

• the majority of mature CD8 T cells in the periphery express the transgenic T cell receptor (TCR) that is specific for influenza virus hemagglutinin (HA) peptide presented by MHC-Class I H2-K^d

• 40% of the CD8 T cells in the blood are reactive to HA peptide presented by H2-K^d

• most thymocytes also express the transgenic TCR

abnormal T cell subpopulation ratio ( J:99756 )

• skewing toward the development of single-positive CD8 T cells is evident in the thymus

• there are 4-fold more CD8 T cells than CD4 T cells found in the lymph nodes