Phenotypes Associated with This Genotype

Genotype
MGI:3789209

cx2

• Allelic Composition: Tg(Ins2-HA)165Bri/?; Tg(TcraCl4,TcrbCl4)1Shrm/?
• Genetic Background: involves: BALB/c * C57BL/6 * C57BL/10

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:99756 )

• neonates die within 7 to 10 days of birth due to complications in glucose metabolism

homeostasis/metabolism

hyperglycemia ( J:99756 )

• one day old mice exhibit hyperglycemia with blood glucose levels averaging over 400 mg/dl

• neonates die within 7 to 10 days of birth due to complications in glucose metabolism

endocrine/exocrine glands

insulitis ( J:99756 )

• pancreas of 1-day old mice are infiltrated by transgenic CD8 T cells

• the presence of infiltrating cells disrupts the normal pancreatic architecture with loss of islet mass and dissemination of the remaining islet beta cell clusters

immune system

insulitis ( J:99756 )

• pancreas of 1-day old mice are infiltrated by transgenic CD8 T cells

• the presence of infiltrating cells disrupts the normal pancreatic architecture with loss of islet mass and dissemination of the remaining islet beta cell clusters