Analysis Tools
mortality/aging
|
• all mice die between 4-6 weeks of age from a fulminate inflammatory bowel disease
|
growth/size/body
|
• mice fail to thrive by 3-4 weeks of age and exhibit rapid weight loss culminating in death between 4-6 weeks of age
|
immune system
|
• the cecum and descending colon of mice 4-6 weeks of age exhibit a defuse and marked thickening of the mucusa accompanied by areas of focal ulceration
• there is extensive epithelial hyperplasia, diminished goblet and crypt cell numbers, erosion of surface epithelial cells, numerous crypt abscesses, and mixed leukocytic infiltrates
• there are 10-fold more immune cells found in the lamina propia compared to controls that consists mainly of T cells, NK cells, monocytes, neutrophils and B cells
• colitis can be ameliorated with either combined anti-IFN gamma/ anti-TNF treatment or with broad-spectrum antibiotic treatment
• transferred CD4 T cells from 3 week old mice are able to induce colitis with a similar pathology in immunodeficient recipients
|
|
• inflammation extends into the rectum with significant loss of epithelial crypts and increased width of crypts
• epithelial hyperplasia also occurs as indicated by increased crypt height and elevated M-phase cells per crypt
• an increase in the apoptotic index of rectal epithelial cells and a decrease in epithelial cell height are also observed
|
|
• there is an 18-fold increase in IFN-gamma levels in the sera of 4-5 week old mice
• elevated levels of IFN-gamma are also detected in colon explants from 4-5 week old mice
|
|
• there is a 19-fold increase in IL-6 levels in the sera of 4-5 week old mice
|
|
• there is a 6-fold increase in TNF levels in the sera of 4-5 week old mice
|
|
• there is an increased percentage of CD4 T cells producing IFN-gamma in the mesenteric lymph nodes and the lamina propria of 4-5 week old mice
• there is also an increase in the percentage of CD8 T cells producing IFN-gamma compared to wild-type mice
• elevated levels of IFN-gamma are also detected from colon explants of 4-5 week old mice
|
|
• there is an increased percentage of CD4 T cells producing IL-17 in the mesenteric lymph nodes of 4-5 week old mice compared to controls
|
|
• 32.6% of T cells produce TNF compared to 23.8% of wild-type mice
|
|
• small occasional clusters of lymphocytes are located in the portal triads of mice over 4 weeks of age
|
|
• small occasional clusters of lymphocytes are located around the bronchi of the lungs
|
digestive/alimentary system
|
• the cecum and descending colon of mice 4-6 weeks of age exhibit a defuse and marked thickening of the mucusa accompanied by areas of focal ulceration
• there is extensive epithelial hyperplasia, diminished goblet and crypt cell numbers, erosion of surface epithelial cells, numerous crypt abscesses, and mixed leukocytic infiltrates
• there are 10-fold more immune cells found in the lamina propia compared to controls that consists mainly of T cells, NK cells, monocytes, neutrophils and B cells
• colitis can be ameliorated with either combined anti-IFN gamma/ anti-TNF treatment or with broad-spectrum antibiotic treatment
• transferred CD4 T cells from 3 week old mice are able to induce colitis with a similar pathology in immunodeficient recipients
|
|
• inflammation extends into the rectum with significant loss of epithelial crypts and increased width of crypts
• epithelial hyperplasia also occurs as indicated by increased crypt height and elevated M-phase cells per crypt
• an increase in the apoptotic index of rectal epithelial cells and a decrease in epithelial cell height are also observed
|
homeostasis/metabolism
|
• there is an 18-fold increase in IFN-gamma levels in the sera of 4-5 week old mice
• elevated levels of IFN-gamma are also detected in colon explants from 4-5 week old mice
|
|
• there is a 19-fold increase in IL-6 levels in the sera of 4-5 week old mice
|
|
• there is a 6-fold increase in TNF levels in the sera of 4-5 week old mice
|
liver/biliary system
|
• small occasional clusters of lymphocytes are located in the portal triads of mice over 4 weeks of age
|
respiratory system
|
• small occasional clusters of lymphocytes are located around the bronchi of the lungs
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| inflammatory bowel disease | DOID:0050589 |
OMIM:PS266600 |
J:134156 | |
