Phenotypes Associated with This Genotype

Genotype
MGI:3790701

cx10

• Allelic Composition: Itgb2^tm1Bay/Itgb2^tm1Bay; Psrs1^PL/J/Psrs1^PL/J
• Genetic Background: B6.Cg-(D10Mit126-D10Mit38) Itgb2^tm1Bay

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

rheumatoid arthritis ( J:134251 )

• increased susceptibility to rheumatoid arthritis

• 75% incidence of rheumatoid arthritis at 16 weeks of age

• presence of swelling and erythema at ankle joints and tarsometarasal/metatarsophalangeal paw joints

• presence of inflammatory cell infiltrates in bones

• cartilage damage

skeleton

rheumatoid arthritis ( J:134251 )

• increased susceptibility to rheumatoid arthritis

• 75% incidence of rheumatoid arthritis at 16 weeks of age

• presence of swelling and erythema at ankle joints and tarsometarasal/metatarsophalangeal paw joints

• presence of inflammatory cell infiltrates in bones

• cartilage damage

integument

psoriasis ( J:134251 )

• increased psoriasis susceptibility

• 87.5% incidence of psoriasis at 16 weeks of age

• severe progressive erythema and scale and crust formation on the back skin

• presence of epidermal hyperplasia, hyperorthokeratosis and subcorneal microabscesses

• presence of inflammatory cell infiltration (CD4+ cells and macrophages) in the dermis