Phenotypes Associated with This Genotype

Genotype
MGI:3790760

• Allelic Composition: Tg(H2-Ea-G6pc2)69Tkay/?
• Genetic Background: NOD-Tg(H2-Ea-G6pc2)69Tkay

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell proliferation ( J:117352 )

• G6pc2_206-214-specific CD8+ T cells transferred from Tg(TcraTcrbNY8.3)1Pesa NOD mice proliferate extensively in peripheral and other lymph nodes

insulitis ( J:117352 )

• mice develop insulitis with similar incidence and severity as non-transgenic controls

abnormal CD8-positive, alpha beta T cell morphology ( J:117352 )

• T cells specific for IGRP_206-214 (G6pc2_206-214) are not detected in peripheral blood

• a complete absence of G6pc2_206-214-specific CD8+ T cells is observed in expanded, cultured islet-infiltrating T cells compared to 40% of cultured T cells from control littermates

abnormal CD4-positive, alpha-beta T cell physiology ( J:117352 )

• no spontaneous CD4+ T cell response by cultured splenocytes exposed to G6pc2_4-22 peptide is detected in contrast to wild-type NOD mice

abnormal immune tolerance ( J:117352 )

• expanded T cells from pancreatic islets demonstrate tolerance to MHC class I and II-restricted G6pc2 peptides

increased susceptibility to autoimmune diabetes ( J:117352 )

• mice develop Type I diabetes at rate similar to wild-type NOD controls

increased anti-insulin autoantibody level ( J:117352 )

• insulin autoantibodies are elevated in 12-week old transgenic animals, similar to control wild-type NOD mice

hematopoietic system

decreased T cell proliferation ( J:117352 )

• G6pc2_206-214-specific CD8+ T cells transferred from Tg(TcraTcrbNY8.3)1Pesa NOD mice proliferate extensively in peripheral and other lymph nodes

abnormal CD8-positive, alpha beta T cell morphology ( J:117352 )

• T cells specific for IGRP_206-214 (G6pc2_206-214) are not detected in peripheral blood

• a complete absence of G6pc2_206-214-specific CD8+ T cells is observed in expanded, cultured islet-infiltrating T cells compared to 40% of cultured T cells from control littermates

abnormal CD4-positive, alpha-beta T cell physiology ( J:117352 )

• no spontaneous CD4+ T cell response by cultured splenocytes exposed to G6pc2_4-22 peptide is detected in contrast to wild-type NOD mice

endocrine/exocrine glands

insulitis ( J:117352 )

• mice develop insulitis with similar incidence and severity as non-transgenic controls

cellular

decreased T cell proliferation ( J:117352 )

• G6pc2_206-214-specific CD8+ T cells transferred from Tg(TcraTcrbNY8.3)1Pesa NOD mice proliferate extensively in peripheral and other lymph nodes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:117352