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Phenotypes Associated with This Genotype
Genotype
MGI:3790951
ht5
Allelic
Composition		 Lrp2tm1Her/Lrp2+
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp2tm1Her mutation (1 available); any Lrp2 mutation (261 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal ear physiology ( J:134797 )
• uptake of FITC-labeled beta-estrogen into the strial marginal cells is reduced
increased or absent threshold for auditory brainstem response ( J:134797 )
• heterozygotes older than 6 months exhibit a moderate, but significant, elevation in click-ABR threshold
impaired hearing ( J:134797 )
• moderate hearing loss is seen at 6 months of age

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory