Phenotypes Associated with This Genotype

Genotype
MGI:3790955

• Allelic Composition: Stk11^tm1Tpm/Stk11⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

intestine polyps ( J:93361 )

• polyposis detected at 4-5 months

• treatment with celecoxib (Ptgs2 inhibitor) between 3.5 and 10 months reduces number of large polyps observed; similar results are obtained when treatment is performed at 6.5-10 months in mice on 129S7/SvEvBrd * CD-1 background

• microvessel density is reduced in polyps with celecoxib treatment

gastric polyps ( J:93361 )

• polyposis detected at 4-5 months

• treatment with celecoxib (Ptgs2 inhibitor) between 3.5 and 10 months reduces number of large polyps observed; similar results are obtained when treatment is performed at 6.5-10 months in mice on 129S7/SvEvBrd * CD-1 background

• microvessel density is reduced in polyps with celecoxib treatment

neoplasm

decreased tumor incidence ( J:93361 )

• 86% decrease in tumor burden is seen at 10 months in mice treated with celecoxib between 3.5 and 10 months compared to untreated controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Peutz-Jeghers syndrome		DOID:3852	OMIM:175200	J:93361