Phenotypes Associated with This Genotype

Genotype
MGI:3793275

cx2

• Allelic Composition: Atp7b^tx-J/Atp7b^tx-J; Tg(PRNP-APPSweInd)8Dwst/0
• Genetic Background: involves: C3H/HeJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:86701 )

N • survival is increased compared to in Tg(PRNP-APPSweInd)8Dwst mice

homeostasis/metabolism

amyloid beta deposits ( J:86701 )

• mice exhibit a 45% reduction in plaque area compared to in Tg(PRNP-APPSweInd)8Dwst mice due to a reduction in the number of plaques

increased copper level ( J:86701 )

• copper levels are increased compared to in heterozygous Atp7b^tx-J mice

nervous system

amyloid beta deposits ( J:86701 )

• mice exhibit a 45% reduction in plaque area compared to in Tg(PRNP-APPSweInd)8Dwst mice due to a reduction in the number of plaques