Phenotypes Associated with This Genotype

Genotype
MGI:3793299

• Allelic Composition: Ighm^tm1Cgn/Ighm^tm1Cgn; Tg(IghelMD4)4Ccg/Tg(IghelMD4)4Ccg
• Genetic Background: NOD.Cg-Ighm^tm1Cgn Tg(IghelMD4)4Ccg/DvsJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell proliferation ( J:80859 )

• T cells fail to proliferate when splenocytes are cultured in vitro with the diabetes autoantigen GAD

insulitis ( J:80859 )

• mice have low levels of insulitis starting at 12 weeks of age with a mean disease score of 1.62 compared to non-transgenic NOD mice that have a mean score of 3.01 at this age

decreased CD8-positive, alpha-beta T cell number ( J:80859 )

• the number of CD8 T cells found in the spleen is half that of non-transgenic NOD mice

abnormal mature B cell morphology ( J:80859 )

• the number but not the proportion of B cells found in the spleen is twice that of non-transgenic NOD mice

• all of the B cells express the transgenic IgM B cell receptor specific for hen egg lysozyme

abnormal B lymphocyte antigen presentation ( J:80859 )

• purified B cells fail to stimulate T cells from non-transgenic NOD mice when cultured together in the presence of the diabetes autoantigen GAD

decreased susceptibility to autoimmune diabetes ( J:80859 )

• 16.7% of female mice develop diabetes by 21 weeks of age compared to control NOD mice that have an incidence rate of 95.5% at this age

• mice with lymphosarcomas were not included in the analysis

neoplasm

increased lymphoma incidence ( J:80859 )

• lymphosarcomas are present in the majority of mice with development starting at 20 weeks of age

hematopoietic system

abnormal T cell proliferation ( J:80859 )

• T cells fail to proliferate when splenocytes are cultured in vitro with the diabetes autoantigen GAD

decreased CD8-positive, alpha-beta T cell number ( J:80859 )

• the number of CD8 T cells found in the spleen is half that of non-transgenic NOD mice

abnormal mature B cell morphology ( J:80859 )

• the number but not the proportion of B cells found in the spleen is twice that of non-transgenic NOD mice

• all of the B cells express the transgenic IgM B cell receptor specific for hen egg lysozyme

abnormal B lymphocyte antigen presentation ( J:80859 )

• purified B cells fail to stimulate T cells from non-transgenic NOD mice when cultured together in the presence of the diabetes autoantigen GAD

endocrine/exocrine glands

insulitis ( J:80859 )

• mice have low levels of insulitis starting at 12 weeks of age with a mean disease score of 1.62 compared to non-transgenic NOD mice that have a mean score of 3.01 at this age

cellular

abnormal T cell proliferation ( J:80859 )

• T cells fail to proliferate when splenocytes are cultured in vitro with the diabetes autoantigen GAD

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	type 1 diabetes mellitus	DOID:9744	OMIM:222100	J:80859