Phenotypes Associated with This Genotype

Genotype
MGI:3793505

hm2

• Allelic Composition: Spi1^tm1Ram/Spi1^tm1Ram
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:116087 )

• antibiotic-treated mice receiving bone marrow transplants have a life expectancy of 331 +/- 20 days

neonatal lethality, complete penetrance ( J:36473 )

• all mice develop septicemia and die within 24 hours of birth, but mice treated with antibiotics live up to 17 days of age

immune system

abnormal microglial cell morphology ( J:116087 )

• microglia exhibit more prominent, rounded cell bodies and shorter or thicker processes indicating a less differentiated state

abnormal neutrophil differentiation ( J:36473 )

• no mature neutrophils are found in the blood, liver, spleen or bone marrow and fewer immature neutrophils are identified

abnormal macrophage differentiation ( J:36473 )

• no mature macrophages are detected

abnormal T cell differentiation ( J:36473 )

• T cell development is delayed with T cells appearing 3 to 5 days after birth in antibiotic treated mice

decreased double-positive T cell number ( J:36473 )

• in the thymus and periphery

decreased neutrophil cell number ( J:36473 )

• no mature neutrophils are found in the blood, liver, spleen or bone marrow and fewer immature neutrophils are identified

abnormal B cell number ( J:36473 )

absent mature B cells ( J:36473 )

abnormal T cell number ( J:36473 )

decreased thymocyte number ( J:36473 )

• in the thymus and periphery

decreased CD4-positive, alpha-beta T cell number ( J:36473 )

• in the thymus and periphery

decreased CD8-positive, alpha-beta T cell number ( J:36473 )

• in the thymus and periphery

decreased macrophage cell number ( J:36473 )

• no mature macrophages are detected

decreased spleen red pulp amount ( J:36473 )

sepsis ( J:36473 )

• all mice develop septicemia and die within 24 hours of birth

liver/biliary system

dark liver ( J:36473 )

• occasionally mice exhibit a slightly darker red liver than wild-type mice

nervous system

abnormal astrocyte morphology ( J:116087 )

• bone marrow donor cells fail to develop into astrocytes

abnormal microglial cell morphology ( J:116087 )

• microglia exhibit more prominent, rounded cell bodies and shorter or thicker processes indicating a less differentiated state

growth/size/body

postnatal growth retardation ( J:116087 )

• antibiotic-treated mice receiving bone marrow cells from Tg(SOD1*G93A)1Gur mice growing slower than those receiving wild-type bone marrow cells

hematopoietic system

abnormal microglial cell morphology ( J:116087 )

• microglia exhibit more prominent, rounded cell bodies and shorter or thicker processes indicating a less differentiated state

abnormal neutrophil differentiation ( J:36473 )

• no mature neutrophils are found in the blood, liver, spleen or bone marrow and fewer immature neutrophils are identified

abnormal macrophage differentiation ( J:36473 )

• no mature macrophages are detected

abnormal T cell differentiation ( J:36473 )

• T cell development is delayed with T cells appearing 3 to 5 days after birth in antibiotic treated mice

decreased neutrophil cell number ( J:36473 )

• no mature neutrophils are found in the blood, liver, spleen or bone marrow and fewer immature neutrophils are identified

abnormal B cell number ( J:36473 )

absent mature B cells ( J:36473 )

abnormal T cell number ( J:36473 )

decreased thymocyte number ( J:36473 )

• in the thymus and periphery

decreased double-positive T cell number ( J:36473 )

• in the thymus and periphery

decreased CD4-positive, alpha-beta T cell number ( J:36473 )

• in the thymus and periphery

decreased CD8-positive, alpha-beta T cell number ( J:36473 )

• in the thymus and periphery

decreased macrophage cell number ( J:36473 )

• no mature macrophages are detected

decreased spleen red pulp amount ( J:36473 )

cellular

abnormal astrocyte morphology ( J:116087 )

• bone marrow donor cells fail to develop into astrocytes

abnormal microglial cell morphology ( J:116087 )

• microglia exhibit more prominent, rounded cell bodies and shorter or thicker processes indicating a less differentiated state

abnormal neutrophil differentiation ( J:36473 )

• no mature neutrophils are found in the blood, liver, spleen or bone marrow and fewer immature neutrophils are identified

abnormal macrophage differentiation ( J:36473 )

• no mature macrophages are detected

endocrine/exocrine glands

decreased thymocyte number ( J:36473 )

• in the thymus and periphery