Phenotypes Associated with This Genotype

Genotype
MGI:3793622

cx12

• Allelic Composition: Spi1^tm1Ram/Spi1^tm1Ram; Tg(SOD1*G93A)1Gur/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:116087 )

• mice receiving bone marrow from when treated with wild-type bone marrow transfer survive longer than Tg(SOD1*G93A)1Gur mice or mice receiving bone marrow transfers Tg(SOD1*G93A)1Gur mice but not as long as wild-type mice

nervous system

decreased motor neuron number ( J:116087 )

• motor neuron loss is more severe in mice receiving bone marrow transfer from Tg(SOD1*G93A)1Gur mice compared to mice receiving bone marrow transfers from wild-type mice that do not exhibit a significant amount of neuron loss

motor neuron degeneration ( J:116087 )

• antibiotic-treated mice receiving bone marrow cells from wild-type donors exhibit reduced motor neuron disease progression compared to those receiving bone marrow transplants from Tg(SOD1*G93A)1Gur mice

growth/size/body

growth/size/body region phenotype ( J:116087 )

N • antibiotic-treated mice exhibit normal growth rates