Analysis Tools
mortality/aging
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• Background Sensitivity: 79% of mice die between 6 and 14 weeks of age with the likely cause of death being inflammatory lesions of the lungs with generalized pneumoitis
• Background Sensitivity: over 95% of the mice die by 20 weeks of age
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growth/size/body
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• Background Sensitivity: mice are prone to losing weight between 5 and 15 weeks of age with weight loss correlating to the intensity of pancreas or lung inflammation
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immune system
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• Background Sensitivity: sialitis is observed in all mice by 20 weeks of age which is a much higher incidence than what is observed when the mutant allele is on the C57BL/6 or BALB/c backgrounds
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• Background Sensitivity: gastritis occurs in 87% of mice by 20 weeks of age but is rarely observed when the mutant allele is on C57BL/6
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• Background Sensitivity: inflammation of the thyroid occurs in 54% of mice on the NOD background but is not observed in when the mutant allele is present on C57BL/6, BALB/c, or SJL backgrounds
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• Background Sensitivity: all mice have inflammation of the prostate by 20 weeks of age
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• Background Sensitivity: all mice exhibit inflammation of the pancreas on this background while no inflammation is observed in C57BL/6 or BALB/c mice carrying this mutant allele
• Background Sensitivity: the lesions are highly localized within the pancreas and appear to progress from an initial extravasation into the perivascular connective tissue to a front of cell destruction that moves through the exocrine lobe
• Background Sensitivity: islet cells are spared from destruction and the mice remain normoglycemic through 20 weeks of age
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• Background Sensitivity: 88% of mice exhibit inflammation of the ovaries on this background while no inflammation is observed in C57BL/6 mice carrying the mutant allele
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• Background Sensitivity: mice generate autoantibodies with a reactivity that mirror the histopathology associated with this mouse strain
• Background Sensitivity: the autoantibodies generated on the NOD background target numerous tissues including the pancreas
• Background Sensitivity: the pancreas is not targeted by autoantibodies when the mutant allele is present on other genetic backgrounds
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• Background Sensitivity: cornea inflammation occurs in 14% of mice of this background by 20 weeks of age but is not observed when the mutant allele is when the mutant allele is on the SJL or C57BL/6 background
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• Background Sensitivity: liver inflammation is observed in 86% of mice by 20 weeks of age while no inflammation is present when the mutant allele is on the C57BL/6 background
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• Background Sensitivity: lung inflammation is observed in 100% of mice by 20 weeks of age which is a much higher incidence than observed when the mutant allele is on the C57BL/6 background
• Background Sensitivity: lesions of the lung are severe enough to likely cause the runting and premature death associated with this strain
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vision/eye
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• Background Sensitivity: cornea inflammation occurs in 14% of mice of this background by 20 weeks of age but is not observed when the mutant allele is when the mutant allele is on the SJL or C57BL/6 background
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• Background Sensitivity: retinal degeneration resulting from autoimmune disease occurs by 20 weeks of age in 93% of mice
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endocrine/exocrine glands
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• Background Sensitivity: sialitis is observed in all mice by 20 weeks of age which is a much higher incidence than what is observed when the mutant allele is on the C57BL/6 or BALB/c backgrounds
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• Background Sensitivity: inflammation of the thyroid occurs in 54% of mice on the NOD background but is not observed in when the mutant allele is present on C57BL/6, BALB/c, or SJL backgrounds
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• Background Sensitivity: all mice have inflammation of the prostate by 20 weeks of age
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• Background Sensitivity: all mice exhibit inflammation of the pancreas on this background while no inflammation is observed in C57BL/6 or BALB/c mice carrying this mutant allele
• Background Sensitivity: the lesions are highly localized within the pancreas and appear to progress from an initial extravasation into the perivascular connective tissue to a front of cell destruction that moves through the exocrine lobe
• Background Sensitivity: islet cells are spared from destruction and the mice remain normoglycemic through 20 weeks of age
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• Background Sensitivity: 88% of mice exhibit inflammation of the ovaries on this background while no inflammation is observed in C57BL/6 mice carrying the mutant allele
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liver/biliary system
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• Background Sensitivity: liver inflammation is observed in 86% of mice by 20 weeks of age while no inflammation is present when the mutant allele is on the C57BL/6 background
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reproductive system
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• Background Sensitivity: all mice have inflammation of the prostate by 20 weeks of age
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• Background Sensitivity: 88% of mice exhibit inflammation of the ovaries on this background while no inflammation is observed in C57BL/6 mice carrying the mutant allele
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respiratory system
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• Background Sensitivity: lung inflammation is observed in 100% of mice by 20 weeks of age which is a much higher incidence than observed when the mutant allele is on the C57BL/6 background
• Background Sensitivity: lesions of the lung are severe enough to likely cause the runting and premature death associated with this strain
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digestive/alimentary system
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• Background Sensitivity: sialitis is observed in all mice by 20 weeks of age which is a much higher incidence than what is observed when the mutant allele is on the C57BL/6 or BALB/c backgrounds
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• Background Sensitivity: gastritis occurs in 87% of mice by 20 weeks of age but is rarely observed when the mutant allele is on C57BL/6
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autoimmune polyendocrine syndrome type 1 | DOID:0050167 |
OMIM:240300 |
J:107432 | |
