homeostasis/metabolism
• significant reduction in serum copper (mostly found in ceruplasmin) in males is observed
|
• brain levels are reduced by 66% compared to wild-type males
|
• copper levels in brain are reduced by 40%
|
• 7-10 day-old males show an accumulation of copper in the intestinal wall
|
• 7-10 day-old males have significantly reduced (by >2-fold) liver copper levels
|
liver/biliary system
• 7-10 day-old males have significantly reduced (by >2-fold) liver copper levels
|
nervous system
• copper levels in brain are reduced by 40%
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
Menkes disease | DOID:1838 |
OMIM:309400 |
J:5462 |