Phenotypes Associated with This Genotype

Genotype
MGI:3793864

• Allelic Composition: Atp7a^Mo-blo/Y
• Genetic Background: B6.Cg-Atp7a^Mo-blo/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

osteoarthritis ( J:36378 )

♂ • at 2-4 months of age, femoral-tibial joints show structural and cellular changes correlating with mild to moderate osteoarthritis; changes increase in severity with age

♂ • at 10 months, loss of integrity of weight bearing regions of the joints is detected, with cellular changes including cloning and cell loss

abnormal cartilage morphology ( J:36378 )

♂ • 2 month-old mice show decreased collagen crosslinks in cartilage compared to wild-type

♂ • lesions such as defects in cartilage integrity are observed in joints at 10 months of age

immune system

osteoarthritis ( J:36378 )

♂ • at 2-4 months of age, femoral-tibial joints show structural and cellular changes correlating with mild to moderate osteoarthritis; changes increase in severity with age

♂ • at 10 months, loss of integrity of weight bearing regions of the joints is detected, with cellular changes including cloning and cell loss

cellular

oxidative stress ( J:105736 )

♂ • vascular superoxide anion production is increased in all layers of aortas in mutants compared to controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
osteoarthritis		DOID:8398		J:36378