Phenotypes Associated with This Genotype

Genotype
MGI:3794207

• Allelic Composition: Tg(ACTA1-Ar)141Kyjo/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:127205 )

• female mice treated with normal male levels of testosterone die after 9 days of treatment

decreased survivor rate ( J:127205 )

• very few male mice survive to weaning

neonatal lethality, incomplete penetrance ( J:127205 )

• male mice exhibit reduced viability at birth

• however, treatment with flutamide enhances male perinatal survival

muscle

abnormal skeletal muscle fiber morphology ( J:127205 )

• male mice exhibit atrophic and hypertrophic fibers, internal myonuclei, fiber splitting, altered myofibrillar organization and an overall increase in oxidative metabolism

• however, no inflammation is present in muscles and female mice treated with normal male levels of testosterone fail to exhibit muscle loss

increased skeletal muscle fiber size ( J:127205 )

• in male mice

decreased skeletal muscle fiber number ( J:127205 )

• male mice exhibit decreased muscle fiber number by half in the extensor digitorum longus compared to in wild-type mice

muscular atrophy ( J:127205 )

• in male mice

muscle weakness ( J:127205 )

• in male mice

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:127205 )

• male mice and female mice treated with normal male levels of testosterone exhibit decreased motor function that precedes loss of body weight in the case of the females

• however, castration of males improves motor function

short stride length ( J:127205 )

• in male mice

nervous system

abnormal axon morphology ( J:127205 )

• male mice exhibit fewer L5 motor axons than in wild-type mice without neuron loss

growth/size/body

decreased body weight ( J:127205 )

• in male mice and female mice treated with normal male levels of testosterone

skeleton

kyphosis ( J:127205 )

• in male mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Kennedy's disease		DOID:0060161	OMIM:313200	J:127205