Phenotypes Associated with This Genotype

Genotype
MGI:3794450

• Allelic Composition: Tg(Pmp22)247Ueli/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal Schwann cell morphology ( J:98118 )

• Schwann cell density is increased from P21 onwards compared to in wild-type mice

• however, Schwann cell proliferation is normal at P21

• beginning at P4, Schwann cell apoptosis rates are double wild-type rates

abnormal myelination ( J:98118 )

• mice exhibit almost complete amyelination

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Charcot-Marie-Tooth disease type 1A		DOID:0110148	OMIM:118220	J:98118