Analysis Tools
mortality/aging
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• embryoes that express the cre knock-in allele during development die at birth from respiratory distress
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growth/size/body
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• E18.5 embryos are smaller than controls
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limbs/digits/tail
short tail
(
J:134264
)
|
• E18.5 pups have shortened or absent tails
|
absent tail
(
J:134264
)
|
• E18.5 pups have shortened or absent tails
|
respiratory system
atelectasis
(
J:134264
)
|
• the airways and alveoli of E18.5 embryos are collapsed
|
|
• pups die at birth from apparent respiratory failure
|
skeleton
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• 18.5 embryos have incomplete closure of the sternum
|
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• 18.5 embryos have an assymmetric fusion of the ribs to the sternum
|
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• 14 of 15 embryos have one to three additional ribs attached to the sternum
|
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• 10 of 15 embryos have 3 to 4 additional thoracic vertebrae, 8 lumbar vertebrae, and only three to nine sacral and caudal vertebrae
• none of the embryos have the normal complement of vertebraes
|
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• ossification is retarded namely in the mandibles, nasal bone, vertebrae and limbs
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renal/urinary system
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• all E18.5 embryos lack at least one kidney with only 1/6th of the mice having a normal kidney
|
digestive/alimentary system
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• most E18.5 embryos have abdominal herniations
|
cardiovascular system
hemorrhage
(
J:134264
)
|
• subepidermal hemorrhages occur on the head or along the spine amongst the smallest 18.5 embryos
|
