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Phenotypes Associated with This Genotype
Genotype
MGI:3796611
cx11
Allelic
Composition		 Bidtm1Sjk/Bidtm1Sjk
Relatm1Bal/Relatm1Bal
Genetic
Background		 involves: 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bidtm1Sjk mutation (1 available); any Bid mutation (45 available)
Relatm1Bal mutation (1 available); any Rela mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:117693 )
• mice die around the same time as Relatm1Bal homozygotes: Bid deletion does not rescue the lethality

liver/biliary system
liver hemorrhage ( J:132334 )
• at E14.5 and 15.5, embryos show similar level of liver hemorrhaging as control Rela-null embryos
abnormal liver morphology ( J:132334 )
• at E14.5 and 15.5, embryos show similar level of liver destruction as control Rela-null embryos

cardiovascular system
liver hemorrhage ( J:132334 )
• at E14.5 and 15.5, embryos show similar level of liver hemorrhaging as control Rela-null embryos

cellular
decreased fibroblast apoptosis ( J:117693 )
• mouse embryonic fibroblasts are partially protected from TNF-alpha-induced apoptosis compared to exposed Relatm1Bal homozygous mouse embryonic fibroblasts

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory