Phenotypes Associated with This Genotype

Genotype
MGI:3796611

cx11

• Allelic Composition: Bid^tm1Sjk/Bid^tm1Sjk; Rela^tm1Bal/Rela^tm1Bal
• Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:117693 )

• mice die around the same time as Rela^tm1Bal homozygotes: Bid deletion does not rescue the lethality

liver/biliary system

liver hemorrhage ( J:132334 )

• at E14.5 and 15.5, embryos show similar level of liver hemorrhaging as control Rela-null embryos

abnormal liver morphology ( J:132334 )

• at E14.5 and 15.5, embryos show similar level of liver destruction as control Rela-null embryos

cardiovascular system

liver hemorrhage ( J:132334 )

• at E14.5 and 15.5, embryos show similar level of liver hemorrhaging as control Rela-null embryos

cellular

decreased fibroblast apoptosis ( J:117693 )

• mouse embryonic fibroblasts are partially protected from TNF-alpha-induced apoptosis compared to exposed Rela^tm1Bal homozygous mouse embryonic fibroblasts