Phenotypes Associated with This Genotype

Genotype
MGI:3797216

cn1

• Allelic Composition: Meox2^tm1(cre)Sor/Meox2⁺; Pcsk5^tm2Prat/Pcsk5^tm2.1Prat
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

right aortic arch ( J:136243 )

vascular ring ( J:136243 )

• mice exhibit an aortic vascular ring

abnormal heart morphology ( J:136243 )

• cardiac malformations

double outlet right ventricle ( J:136243 )

transposition of great arteries ( J:136243 )

atrial septal defect ( J:136243 )

dextrocardia ( J:136243 )

• dextroposition (one of four)

ventricular septal defect ( J:136243 )

skeleton

abnormal skeleton morphology ( J:136243 )

• mice exhibit axial and appendicular skeletal defects similar to those in Pcsk5^vcc homozygotes

abnormal vertebral column morphology ( J:136243 )

• mice exhibit a presacral mass protruding ventrally from the caudal end of the spinal cord and vertebral column in mice lacking a tail

digestive/alimentary system

abnormal palate morphology ( J:136243 )

• absent

tracheoesophageal fistula ( J:136243 )

limbs/digits/tail

short hindlimb ( J:136243 )

short tail ( J:136243 )

• in some mice

absent tail ( J:136243 )

• in some mice

respiratory system

tracheoesophageal fistula ( J:136243 )

pulmonary hypoplasia ( J:136243 )

• in the left lung

renal/urinary system

absent kidney ( J:136243 )

nervous system

abnormal spinal cord morphology ( J:136243 )

• mice exhibit a presacral mass protruding ventrally from the caudal end of the spinal cord and vertebral column in mice lacking a tail

craniofacial

abnormal palate morphology ( J:136243 )

• absent

growth/size/body

abnormal palate morphology ( J:136243 )

• absent

omphalocele ( J:136243 )