Phenotypes Associated with This Genotype

Genotype
MGI:3797266

hm1

• Allelic Composition: Prkg1^tm2.1Naw/Prkg1^tm2.1Naw
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:134928 )

• mice have a median survival time of under 6 weeks

hematopoietic system

enlarged spleen ( J:134639 )

• splenomegaly first occurs between 5 and 10 weeks of age

• spleens are about 3-fold larger based upon organ/bodyweight ratio

• splenomegaly is evident in most 8 to 10 week old mice splenomegaly is evident in most 8 to 10 week old mice

anemia ( J:134639 )

• mice are anemic by 3-4 weeks of age, which is before the first signs of enlarged spleens

abnormal erythrocyte morphology ( J:134639 )

• red blood cells have about 2-fold higher levels of apoptosis when incubated in Ringer's solution

• red blood cells are also slightly but significantly more flexible in mechanical stress tests

decreased erythrocyte cell number ( J:134639 )

• there is a 52% decrease in the number of red blood cells

decreased hematocrit ( J:134639 )

• hematocrit is significantly decreased

increased mean corpuscular hemoglobin ( J:134639 )

• mice have a significant increase in their mean corpuscular hemoglobin content

increased mean corpuscular volume ( J:134639 )

• there is about a 40% increase in the MCV

increased red blood cell distribution width ( J:134639 )

• the red blood cell distribution width is increased

reticulocytosis ( J:134639 )

• the reticulocyte number is higher in these mice than in control mice

increased erythrocyte clearance ( J:134639 )

• red blood cells are cleared from circulation almost 3-fold faster than in control mice

digestive/alimentary system

abnormal intestinal transit time ( J:134928 )

• intestinal transit time is significantly prolonged in these mice

cardiovascular system

increased mean systemic arterial blood pressure ( J:134928 )

• the mean arterial blood pressure of conscious mice is 11.5% higher than in control mice

• blood pressure is also elevated in unconscious mice and is unresponsive to nitrous oxide realizing drugs

abnormal vascular smooth muscle physiology ( J:134928 )

• cGMP fails to reduce norepinephrine-induced or potassium-induced calcium transients in vascular smooth muscle cells

muscle

abnormal vascular smooth muscle physiology ( J:134928 )

• cGMP fails to reduce norepinephrine-induced or potassium-induced calcium transients in vascular smooth muscle cells

homeostasis/metabolism

abnormal circulating hormone level ( J:134639 )

• there is about a 2-fold increase in erythropoietin plasma levels

immune system

enlarged spleen ( J:134639 )

• splenomegaly first occurs between 5 and 10 weeks of age

• spleens are about 3-fold larger based upon organ/bodyweight ratio

• splenomegaly is evident in most 8 to 10 week old mice splenomegaly is evident in most 8 to 10 week old mice

growth/size/body

enlarged spleen ( J:134639 )

• splenomegaly first occurs between 5 and 10 weeks of age

• spleens are about 3-fold larger based upon organ/bodyweight ratio

• splenomegaly is evident in most 8 to 10 week old mice splenomegaly is evident in most 8 to 10 week old mice