mortality/aging
• some adult mice died suddenly and were fount to have concentric left ventricle hypertrophy
|
• some fetuses died at birth
|
cardiovascular system
• some myofiber showed enlarged nuclei, abnormal vacuolization
• a marked increase in mitochondria and accumulation of lipid droplets
|
• hypertrophied papillary muscles
|
• significant increased heart weights, as well as increased heart-to-body weight ratio
|
• fetuses died at birth show severe cardiac hypertrophy
|
• some adult mice died suddenly and were found to have concentric left ventricle hypertrophy
|
• thickened aortic valve leaflets with poor opening
|
• described as poor opening
|
• in some adult animals showing symptoms of LVH cardiomyopathy
|
• in some adult animals showing symptoms of LVH cardiomyopathy
|
muscle
• some myofiber showed enlarged nuclei, abnormal vacuolization
• a marked increase in mitochondria and accumulation of lipid droplets
|
• hypertrophied papillary muscles
|
• some adult mice died suddenly and were found to have concentric left ventricle hypertrophy
|
• in some adult animals showing symptoms of LVH cardiomyopathy
|
• a marked enlargement of the SR and large perinuclear vacuoles
|
growth/size/body
• significant increased heart weights, as well as increased heart-to-body weight ratio
|
• fetuses died at birth show severe cardiac hypertrophy
|
• some adult mice died suddenly and were found to have concentric left ventricle hypertrophy
|
cellular
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
X-linked dilated cardiomyopathy | DOID:0110461 |
OMIM:302045 |
J:136798 |