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Phenotypes Associated with This Genotype
Genotype
MGI:3797627
Allelic
Composition
Xlch/?
Genetic
Background
C57BL/6J-Xlch
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• some adult mice died suddenly and were fount to have concentric left ventricle hypertrophy
• some fetuses died at birth

cardiovascular system
• some myofiber showed enlarged nuclei, abnormal vacuolization
• a marked increase in mitochondria and accumulation of lipid droplets
• hypertrophied papillary muscles
• significant increased heart weights, as well as increased heart-to-body weight ratio
• fetuses died at birth show severe cardiac hypertrophy
• some adult mice died suddenly and were found to have concentric left ventricle hypertrophy
• thickened aortic valve leaflets with poor opening
• described as poor opening
• in some adult animals showing symptoms of LVH cardiomyopathy
• in some adult animals showing symptoms of LVH cardiomyopathy

muscle
• some myofiber showed enlarged nuclei, abnormal vacuolization
• a marked increase in mitochondria and accumulation of lipid droplets
• hypertrophied papillary muscles
• some adult mice died suddenly and were found to have concentric left ventricle hypertrophy
• in some adult animals showing symptoms of LVH cardiomyopathy
• a marked enlargement of the SR and large perinuclear vacuoles

growth/size/body
• significant increased heart weights, as well as increased heart-to-body weight ratio
• fetuses died at birth show severe cardiac hypertrophy
• some adult mice died suddenly and were found to have concentric left ventricle hypertrophy

cellular

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
X-linked dilated cardiomyopathy DOID:0110461 OMIM:302045
J:136798


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory